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Enzyme induction in the elderly: Effect of rifampin on the pharmacokinetics and pharmacodynamics of propafenone

โœ Scribed by Dilger, K


Book ID
111726784
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
63 KB
Volume
67
Category
Article
ISSN
0009-9236

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In a cross-sectional study of the pharmacokinetics and pharmacodynamics of peroral and intravenous bumetanide (0.5 mg, single dose), total and renal clearance of the diuretic was si~ni6cantly lower in elderly persons than in young adults, resulting in higher bumetanide plasma levels in the aged. Non