## Abstract The interaction between indomethacin (IND) and methotrexate (MTX) was investigated in rabbits. The study was designed so as to evaluate the effect of IND (1 mg h^โ1^) during a continuous MTX infusion (1ยท2 mg kg^โ1^) over 240 min. IND was injected i.v. at hourly intervals after a steady
Effects of indomethacin on the pharmacokinetics and pharmacodynamics of prednisolone in rats
โ Scribed by Varun Garg; William J. Jusko
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 425 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The effect of omeprazole on oral and intravenous (iv) RS-methadone pharmacokinetics and pharmacodynamics was studied in awake, freely moving rats, which were divided in four groups: oral RS-methadone (3 mg/kg) was given (a) to a control group (CO(oral)) (n = 65) and (b) to an omeprazole pretreated g
Gender differences in pharmacokinetics and pharmacodynamics of azosemide were evaluated after intravenous, 10 mg kg -1 , and oral, 10 mg kg -1 , administration to male and female rats. After intravenous administration to male rats, the percentages of intravenous dose of azosemide recovered from enti
The aim of our study was to evaluate the influence of low-intensity exercise on levodopa absorption and levodopa motor effect. We studied the pharmacokinetics and pharmacodynamics of levodopa under resting conditions and under a workload of 50 watts for 2 hours on a cycle ergometer in 12 parkinsonia
The eects of pretreatment with the enzyme inducers phenobarbital (PB) and 3methylcholanthrene (3-MC) and the enzyme inhibitor chloramphenicol (CM) on the pharmacokinetic and pharmacodynamic parameters of azosemide were examined after intravenous (IV) administration of azosemide, 10 mg kg 71 , to rat