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Gender differences in pharmacokinetics and pharmacodynamics of azosemide in rats

✍ Scribed by Young S. Lee; Kye S. Han; Myung G. Lee

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 122 KB
Volume: 20
Category: Article
ISSN: 0142-2782
DOI: 10.1002/(sici)1099-081x(199905)20:4<225::aid-bdd176>3.0.co;2-e

No coin nor oath required. For personal study only.

✦ Synopsis

Gender differences in pharmacokinetics and pharmacodynamics of azosemide were evaluated after intravenous, 10 mg kg -1 , and oral, 10 mg kg -1 , administration to male and female rats. After intravenous administration to male rats, the percentages of intravenous dose of azosemide recovered from entire gastrointestinal tract at 24 h (13.2 versus 3.93%) was significantly greater than those in female rats. In male rats, the nonrenal clearance of azosemide tended (pB 0.066) to be faster and kidney weight tended (p B0.068) to be greater than those in female rats. After oral administration of azosemide to male rats, the 8-h urinary excretion of potassium (0.395 versus 0.766 mmol g -1 kidney) and 8-h kaluretic efficiency (55.9 versus 284 mmol mg -1 ) decreased significantly compared with female rats.

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