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Effects ofAcanthopanax senticosusHARMS extract on drug transport in human intestinal cell line Caco-2

✍ Scribed by Tsunehisa Takahashi; Tomomi Kaku; Takashi Sato; Kazuhiro Watanabe; Juichi Sato

Book ID
107343765
Publisher
Springer Japan
Year
2009
Tongue
Japanese
Weight
275 KB
Volume
64
Category
Article
ISSN
1340-3443

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi