Effects of training on exercise-induced muscle damage and interleukin 6 production

✍ Scribed by J.-L. Croisier; G. Camus; I. Venneman; G. Deby-Dupont; A. Juchmès-Ferir; M. Lamy; J.-M. Crielaard; C. Deby; J. Duchateau

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 106 KB
• Volume: 22
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/(sici)1097-4598(199902)22:2<208::aid-mus8>3.0.co;2-b

✦ Synopsis

To address the question of whether the increased plasma concentration of interleukin 6 (IL-6) following strenuous muscular work could be related to exercise-induced muscle damage, 5 moderately active male volunteers underwent two isokinetic exercise sessions in the eccentric mode, separated by a period of 3 weeks during which the subjects underwent five training sessions. Before training, exercise was followed by severe muscle pain (delayed-onset muscle soreness; DOMS), and by significant increases in plasma IL-6 level and serum myoglobin concentration (SMb) (P < 0.001). After training, postexercise DOMS and SMb values were significantly lower than those measured before training. There was no significant difference between plasma IL-6 levels measured at the same time points before and after training. We conclude that the hypothetical relationship between exercise-induced muscle damage and increased postexercise levels of circulating IL-6 is not substantiated by the present results.