✦ LIBER ✦

Effects of interleukin-1 and dexamethasone on interleukin-6 production and growth in human meningiomas

✍ Scribed by Jones, T. Hugh; Justice, Susan K.; Timperley, Walter R.; Royds, Janice A.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 200 KB
Volume: 183
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199712)183:4<460::aid-path961>3.0.co;2-z

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✦ Synopsis

Interleukin-6 (IL-6) has been shown to be released by cultured human meningioma cells and may be a positive or negative regulator of tumour growth. IL-6 protein and mRNA levels have been examined in a series of meningiomas. In 14 cases, the results are compared with the effects of IL-6 and dexamethasone on growth and IL-6 secretion in vitro. Tumours with the highest in vivo IL-6 mRNA expression also showed maximum induction of IL-6 and increased cellular proliferation on IL-1 stimulation in vitro. Dexamethasone decreased the IL-1-stimulated IL-6 release in all cases. Meningiomas which had little or no IL-6 message were refractory to IL-1 control of IL-6. Remarkably, these formed the group of meningiomas that increased their growth rate in response to dexamethasone. 1997

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