Protective Effect of a Lignan-enriched Extract of Fructus schisandrae on Physical Exercise Induced Muscle Damage in Rats
✍ Scribed by K. M. Ko; Duncan H. F. Mak; P. C. Li; M. K. T. Poon; S. P. Ip
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 243 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
We have demonstrated that pretreatment with a lignan-enriched extract of Fructus schisundrue (FS) protected against physical exercise-induced muscle damage in rats. The muscle protection afforded by FS pretreatment was associated with a significant enhancement in hepatic antioxidant status, as assessed by hepatic glutathione (GSH) and malondialdehyde (MDA) levels. Pretreating rats with a-tocopherol acetate, though decreasing the MDA level in skeletal muscle, did not protect against exercise-induced muscle damage or improve hepatic antioxidant status in exercised rats. The results indicate that the protective effect of FS pretreatment on physical exercise-induced muscle damage may result from the enhancement of hepatic GSH status, thereby providing sufficient GSH for effective antioxidant protection of skeletal muscle during exercise.