Effects of talipexole on motor behavior in normal and MPTP-treated common marmosets
โ Scribed by Masahiro Irifune; Masahiro Nomoto; Takeo Fukuda
- Book ID
- 115888928
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 543 KB
- Volume
- 238
- Category
- Article
- ISSN
- 0014-2999
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๐ SIMILAR VOLUMES
Oral administration of levodopa (L-dopa) (2.5-25.0 mg/kg) plus carbidopa (12.5 mg/kg p.o.) to MPTP-treated common marmosets produced a dose-related increase in locomotor activity and a corresponding decrease in motor disability. Pretreatment with the peripheral COMT inhibitor entacapone (12.5 mg/kg
## Abstract Longโacting full dopamine D~2~ agonists produce less dyskinesia in 1โmethylโ4โphenylโ1,2,3,6โtetrahydropyridine (MPTP)โtreated primates and in Parkinson's disease than effective antiparkinsonian doses of levodopa. They do not however, prevent priming for dyskinesia expression on subsequ
## Abstract Reduced expression of dyskinesia is observed in levodopaโprimed MPTPโtreated common marmosets when dopamine agonists are used to replace levodopa. We now investigate whether a combination of the Dโ2/Dโ3 agonist pramipexole and levodopa also reduces dyskinesia intensity while maintaining