Effects of ropinirole on motor behavior in MPTP-treated common marmosets
β Scribed by Koichiro Fukuzaki; Takeshi Kamenosono; Kazuhiro Kitazumi; Ryoichi Nagata
- Book ID
- 114102064
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 203 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0091-3057
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Oral administration of levodopa (L-dopa) (2.5-25.0 mg/kg) plus carbidopa (12.5 mg/kg p.o.) to MPTP-treated common marmosets produced a dose-related increase in locomotor activity and a corresponding decrease in motor disability. Pretreatment with the peripheral COMT inhibitor entacapone (12.5 mg/kg
## Abstract Longβacting full dopamine D~2~ agonists produce less dyskinesia in 1βmethylβ4βphenylβ1,2,3,6βtetrahydropyridine (MPTP)βtreated primates and in Parkinson's disease than effective antiparkinsonian doses of levodopa. They do not however, prevent priming for dyskinesia expression on subsequ