## Abstract Long‐term dopamine replacement therapy of Parkinson's disease leads to the occurrence of dyskinesias. Altered firing patterns of neurons of the internal globus pallidus, involving a pathological synchronization/desynchronization process, may contribute significantly to the genesis of dy
Decreased expression of l-dopa-induced dyskinesia by switching to ropinirole in MPTP-treated common marmosets
✍ Scribed by Michael J. Jackson; Lance A. Smith; Ghassan Al-Barghouthy; Sarah Rose; Peter Jenner
- Book ID
- 116459057
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 242 KB
- Volume
- 204
- Category
- Article
- ISSN
- 0014-4886
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## Abstract De novo administration of long‐acting dopamine agonists, such as ropinirole, to patients with Parkinson's disease or to 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐treated subhuman primates produces a lower incidence of dyskinesia than occurs with L‐DOPA. This study compares the