A wide range of motor fluctuations develop in Parkinson's disease (PD) patients after prolonged levodopa (L-dopa) treatment, but few experimental models exist in which these can be investigated. We report on motor fluctuations occurring in MPTP-treated common marmosets (Callithrix jacchus) treated r
Chronic supranigral infusion of BDNF in normal and MPTP-treated common marmosets
✍ Scribed by R. K. B. Pearce; S. Costa; P. Jenner; C. D. Marsden
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 584 KB
- Volume
- 106
- Category
- Article
- ISSN
- 1435-1463
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Oral administration of levodopa (L-dopa) (2.5-25.0 mg/kg) plus carbidopa (12.5 mg/kg p.o.) to MPTP-treated common marmosets produced a dose-related increase in locomotor activity and a corresponding decrease in motor disability. Pretreatment with the peripheral COMT inhibitor entacapone (12.5 mg/kg
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