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Effects of sodium phenylbutyrate on differentiation and induction of the P21WAF1/CIP1 anti-oncogene in human liver carcinoma cell lines

✍ Scribed by MENG, Mei ;JIANG, Jun Mei ;LIU, Hui ;IN, Cheng Yong ;ZHU, Ju Ren


Book ID
108988652
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
97 KB
Volume
6
Category
Article
ISSN
1443-9611

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p21 WAF1/CIP1 is a downstream mediator of p53 and mediates growth arrest by inhibiting the action of G 1 cyclin-dependent kinases. Since cellular differentiation is frequently characterized by G 1 arrest, we examined whether p21 WAF1/CIP1 overexpression would induce growth suppression and differenti