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Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells

✍ Scribed by Yamamoto, Hirofumi; Soh, Jae-Won; Shirin, Haim; Xing, Wang-Qiu; Lim, Jin TE; Yao, Yao; Slosberg, Eric; Tomita, Naohiro; Schieren, Ira; Weinstein, I Bernard


Book ID
110061731
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
801 KB
Volume
18
Category
Article
ISSN
0950-9232

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Overexpression of p21WAF1/CIP1 induces c
✍ Takashi Kokunai; Ichiro Izawa; Norihiko Tamaki πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 French βš– 215 KB πŸ‘ 1 views

p21 WAF1/CIP1 is a downstream mediator of p53 and mediates growth arrest by inhibiting the action of G 1 cyclin-dependent kinases. Since cellular differentiation is frequently characterized by G 1 arrest, we examined whether p21 WAF1/CIP1 overexpression would induce growth suppression and differenti