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Effects of nucleoside analog incorporation on DNA binding to the DNA binding domain of the GATA-1 erythroid transcription factor

โœ Scribed by Matthew Foti; James G Omichinski; Stephen Stahl; Donna Maloney; John West; Barry I Schweitzer


Book ID
117110367
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
316 KB
Volume
444
Category
Article
ISSN
0014-5793

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Modified nucleoside-dependent transition
โœ Anh T. Lam; Richard Guenther; Paul F. Agris ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Springer Netherlands ๐ŸŒ English โš– 729 KB

Biologically active DNA analogs of tRNA Phe (tDNA phi) were used to investigate metal ion interaction with tRNA-like structures lacking the 2'OH. Binding of Mg 2 ยง to the 76 oligonucleotide tDNA ehe, monitored by circular dichroism spectroscopy, increased base stacking and thus the conformational st