## Abstract This report presents a set of investigations on the hepatotoxic action of acetaminophen (AA). Male mice of Balb C strain were given [^3^H]acetaminophen in doses of 100, 300 and 600 mg kg^โ1^ with or without pretreatment with 3โmethylcholanthrene (3MCh) or diethyl maleate (DEM). The res
Effects of nitrogen dioxide and 3-methylcholanthrene on pulmonary enzymes
โ Scribed by F. C. P. Law; J. C. Drach; J. E. Sinsheimer
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 222 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3549
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The effects of pretreatment with the enzyme inducers, phenobarbital (PB) and 3-methylcholanthrene (3-MC), on the pharmacokinetic and pharmacodynamic parameters of bumetanide were examined in rats. The nonrenal clearance (19.3 vs 29.6 ml min-' per kg) of bumetanide increased significantly in PB treat