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The effect of immunity on pulmonary metastasis of a methylcholanthrene-induced fibrosarcoma and three of its clones

✍ Scribed by Samuel Yu; Nancy Wang; Charles F. McKhann

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
612 KB
Volume
27
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

A 3‐Methylcholanthrene (MC)‐induced fibrosarcoma and three of its clones were investigated for their metastatic potential in normal and tumor immune mice. The growth rates of the four tumors in vivo were similar. However, the mean survival times of the tumor‐bearing mice were markedly different. Clone 10, the most immunogenic, showed very high metastatic potential and short survival, while clone 27, the least immunogenic, produced few metastases, resulting in much longer survival. Moderate numbers of metastases were produced by highly immunogenic 3‐AM (parental tumor), and poorly immunogenic clone 34. Spleen cells from mice bearing highly immunogenic tumors lost their ability to neutralize tumors by day 28 after tumor inoculation, while those from mice bearing poorly immunogenic tumors remained cytotoxic, indicating that highly immunogenic tumors also induced immune suppression in the hosts. Immunization with specific tumors decreased the number of pulmonary metastases by 3 to 35‐fold. Immunization with tumors that shared antigens provided protection against metastatic tumors as well as the local tumors. In contrast, immunization with antigenically different tumors gave no protection.

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