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Effects of 3-methylcholanthrene or diethyl maleate on the hepatotoxicity of acetaminophen

✍ Scribed by J. A. Szymańska; E. A. Swietlicka; J. K. Piotrowski; M. Skrzypińska-Gawrysiak; S. Sporny

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
413 KB
Volume
12
Category
Article
ISSN
0260-437X

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✦ Synopsis

Abstract

This report presents a set of investigations on the hepatotoxic action of acetaminophen (AA). Male mice of Balb C strain were given [^3^H]acetaminophen in doses of 100, 300 and 600 mg kg^−1^ with or without pretreatment with 3‐methylcholanthrene (3MCh) or diethyl maleate (DEM).

The results of this study show that AA administered in moderate doses brings about necrotic changes due to adduct formation with macromolecules. Adduct formation was inversely correlated with the level of glutathione.

Both modifiers enhanced hepatic necrosis and lethality. Diethyl maleate exerted these effects without enhancing covalent binding to macromolecules, while 3MCh increased both adduct formation and lipid peroxidation.

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