𝔖 Bobbio Scriptorium

✦ LIBER ✦

Effects of mouse interferon on human tumour xenografts in the nude mouse host

✍ Scribed by F. R. Balkwill; E. Proietti

Publisher: John Wiley and Sons
Year: 1986
Tongue: French
Weight: 575 KB
Volume: 38
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910380312

No coin nor oath required. For personal study only.

✦ Synopsis

Murine interferon (IFN) inhibited the growth of 3/3 human tumour xenografts growing in nude mice. This inhibition was independent of the sensitivity of the xenograft to human IFN. In contrast to human IFN, the murine IFN did not directly affect the human tumour cells in vitro as measured by levels of the IFNinduced enzyme 2-5A synthetase or elevation of HLA expression. In preliminary investigations into the role of the host in the murine IFN-mediated tumour inhibition, we found equal activities of this IFN in nude and in beige (NK-deficient) nude mice. Moreover, murine IFN did not elevate levels of NK-cell activity in either of these mouse strains. We conclude that murine IFN mediates this tumour inhibition via an effect on the tumour-bearing host that may or may not involve immune mechanisms.

📜 SIMILAR VOLUMES

Human interferon inhibits the growth of

Human interferon inhibits the growth of established human breast tumours in the nude mouse

✍ F. R. Balkwill; E. M. Moodie; V. Freedman; K. H. Fantes 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 591 KB

## Abstract In this paper we describe a model system for looking at the effects of human interferon, IFN, on an established human tumour. Highly purified human IFN derived from lymphoblastoid cells (HuIFNα‐Namalwa) strongly inhibited the growth of a human breast cancer growing as a xenograft in nud

Anti-metastatic effect of capecitabine o

Anti-metastatic effect of capecitabine on human colon cancer xenografts in nude mouse rectum

✍ Itasu Ninomiya; Itsuro Terada; Tetsuya Yoshizumi; Takahisa Takino; Noboru Nagai; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 607 KB

## Abstract Capecitabine (__N__ ^4^‐pentyloxycarbonyl‐5′‐deoxy‐5‐fluorocytidine) is a new fluoropyrimidine carbamate, which is converted to 5‐fluorouracil (5‐FU) by 3 sequential steps of enzyme reactions. We investigated the possibility of using capecitabine to prevent metastasis with a metastasis

Metastatic models of human cancer xenogr

Metastatic models of human cancer xenografted in the nude mouse: The importance of orthotopic transplantation

✍ Tetsuro Kubota 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 487 KB

Metastatic model of human tumor xenografts have been developed using orthotopic transplantation of histologically intact tissue (onplantation) of lung, stomach, colon, pancreatic, prostate and bladder carcinomas. These models represent the entire process of the metastasis, consisting of local tumor

The dielectric properties of cancerous t

The dielectric properties of cancerous tissues in a nude mouse xenograft model

✍ Done-Sik Yoo 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB 👁 1 views

Usefulness of the nude mouse model in me

Usefulness of the nude mouse model in mesothelioma based on a direct patient–xenograft comparison

✍ A. Philippe Chahinian; Lenina Szrajer; James F. Holland; Paul A. Kirschner; Rona 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 254 KB 👁 2 views

Metastasis of a human melanoma cell line

Metastasis of a human melanoma cell line in the nude mouse

✍ E. Lynette Wilson; Maria F. R. M. Gartner; J. A. H. Campbell; Eugene B. Dowdle 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 457 KB

A human melanoma cell line has been established which when inoculated subcutaneously into nude mice, is consis-tent1 y metastatic. In order to document blood-borne spread. apparent. Macroscopically detectable metastatic spread at autopsy was reliably indicated by weight loss of the animals. Metastas