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Metastasis of a human melanoma cell line in the nude mouse

✍ Scribed by E. Lynette Wilson; Maria F. R. M. Gartner; J. A. H. Campbell; Eugene B. Dowdle

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
457 KB
Volume
41
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

A human melanoma cell line has been established which when inoculated subcutaneously into nude mice, is consis-tent1 y metastatic. In order to document blood-borne spread. apparent. Macroscopically detectable metastatic spread at autopsy was reliably indicated by weight loss of the animals. Metastases were widespread and involved the lungs, abdominal cavity and organs and the gonads. The size of the primary tumour at the time of its removal, and not the period of S.C. growth, determined the incidence of metastatic disease. Retask, whereas all of the animals showed widely disseminated disease if the turnour was allowed to attain a size of 1.6 g before excision.

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