We aimed to study in detail the in vivo stoichiometry of the individual elements of the 2-step streptavidin based approach to tumour targeting, in a nude mouse xenograft model, by the administration of a first step consisting of biotinylated anti-tumour specific antibody and a second step consisting
✦ LIBER ✦
Usefulness of the nude mouse model in mesothelioma based on a direct patient–xenograft comparison
✍ Scribed by A. Philippe Chahinian; Lenina Szrajer; James F. Holland; Paul A. Kirschner; Ronald E. Gordon
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 254 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
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## Abstract The nonlinear pharmacokinetics of capecitabine, a triple prodrug of 5‐FU preferentially activated in tumour tissues, was investigated in human cancer xenograft models. A physiologically based pharmacokinetic (PBPK) model integrating the activation process of capecitabine to 5‐FU and 5‐F