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Effects of Lipids on ATPase Activity of Purified Chinese Hamster P-Glycoprotein

✍ Scribed by I.L. Urbatsch; A.E. Senior


Book ID
115565366
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
528 KB
Volume
316
Category
Article
ISSN
0003-9861

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Cholesterol promotes basal and verapamil-induced ATPase activity of P-glycoprotein (P-gp). We investigated whether these effects are related to each other and to the impact of the sterol on bilayer fluidity and verapamil membrane affinity. P-gp was reconstituted in egg-phosphatidylcholine (PhC) lipo