Cholesterol-mediated activation of P-gly
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Sara Belli; Priska M. Elsener; Heidi Wunderli-Allenspach; Stefanie D. KrΓ€mer
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Article
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2009
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John Wiley and Sons
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English
β 353 KB
Cholesterol promotes basal and verapamil-induced ATPase activity of P-glycoprotein (P-gp). We investigated whether these effects are related to each other and to the impact of the sterol on bilayer fluidity and verapamil membrane affinity. P-gp was reconstituted in egg-phosphatidylcholine (PhC) lipo