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Effects of cardiovascular drugs on ATPase activity of P-glycoprotein in plasma membranes and in purified reconstituted form

✍ Scribed by James F. Rebbeor; Alan E. Senior


Book ID
117048826
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
735 KB
Volume
1369
Category
Article
ISSN
0005-2736

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Cholesterol promotes basal and verapamil-induced ATPase activity of P-glycoprotein (P-gp). We investigated whether these effects are related to each other and to the impact of the sterol on bilayer fluidity and verapamil membrane affinity. P-gp was reconstituted in egg-phosphatidylcholine (PhC) lipo