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Absence of Cooperativity for MgATP and Verapamil Effects on the ATPase Activity of P-Glycoprotein Containing Membrane Vesicles

โœ Scribed by M. Garrigos; J. Belehradek; L.M. Mir; S. Orlowski

Book ID
115573728
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
404 KB
Volume
196
Category
Article
ISSN
0006-291X

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We have previously shown that amphiphilic diblock copolymers composed of methoxypolyethylene glycol-b-polycaprolactone (MePEG-b-PCL) increased the cellular accumulation and reduced the basolateral to apical flux of the P-glycoprotein substrate, rhodamine 123 (R-123) in caco-2 cells. The purpose of t