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The effects of lipids and detergents on ATPase-active P-glycoprotein

✍ Scribed by Carl A. Doige; Xiaohong Yu; Frances J. Sharom


Book ID
115730502
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
800 KB
Volume
1146
Category
Article
ISSN
0005-2736

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Cholesterol-mediated activation of P-gly
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Cholesterol promotes basal and verapamil-induced ATPase activity of P-glycoprotein (P-gp). We investigated whether these effects are related to each other and to the impact of the sterol on bilayer fluidity and verapamil membrane affinity. P-gp was reconstituted in egg-phosphatidylcholine (PhC) lipo