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Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein

✍ Scribed by Robert L. Shepard; Mark A. Winter; Suzanne C. Hsaio; Homer L. Pearce; William T. Beck; Anne H. Dantzig


Book ID
113994188
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
549 KB
Volume
56
Category
Article
ISSN
0006-2952

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Cholesterol promotes basal and verapamil-induced ATPase activity of P-glycoprotein (P-gp). We investigated whether these effects are related to each other and to the impact of the sterol on bilayer fluidity and verapamil membrane affinity. P-gp was reconstituted in egg-phosphatidylcholine (PhC) lipo