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Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity

โœ Scribed by Thomas Litman; Thomas Zeuthen; Torben Skovsgaard; Wilfred D. Stein


Book ID
117618221
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
307 KB
Volume
1361
Category
Article
ISSN
0925-4439

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Cholesterol promotes basal and verapamil-induced ATPase activity of P-glycoprotein (P-gp). We investigated whether these effects are related to each other and to the impact of the sterol on bilayer fluidity and verapamil membrane affinity. P-gp was reconstituted in egg-phosphatidylcholine (PhC) lipo