Effects of Intestinal and Hepatic Metabolism on the Bioavailability of Tacrolimus in Rats
โ Scribed by Yukiya Hashimoto; Hiroaki Sasa; Masahiro Shimomura; Ken-ichi Inui
- Book ID
- 110308058
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 420 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0724-8741
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๐ SIMILAR VOLUMES
It was reported that the mean value of the extent of absolute oral bioavailability (F) of oltipraz at a dose of 20 mg/kg was 41.2% and only 2.68% of the oral dose was unabsorbed from the gastrointestinal tract in rats. Hence, the low F in rats could be due to considerable first-pass (gastric, intest
The enhancing effects of cyclodextrins (CyDs) on the solubility, the dissolution rate, and the bioavailability of tacrolimus after oral administration to rats were examined and compared with those after administration of a PROGRAF 1 capsule containing the solid dispersion formulation of tacrolimus.