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Effects of hyperoxia and iron on iron regulatory protein-1 activity and the ferritin synthesis in mouse peritoneal macrophages

✍ Scribed by Kazumi Kuriyama-Matsumura; Hideyo Sato; Mika Suzuki; Shiro Bannai


Book ID
114148910
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
530 KB
Volume
1544
Category
Article
ISSN
0167-4838

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Iron is essential for many biological processes, including oxygen delivery, and its supply is tightly regulated. Iron regulatory proteins (IRPs, IRP1 and IRP2) are master regulators of cellular iron metabolism. Hypoxia triggers a broad range of gene responses that are primarily mediated by hypoxia-i