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Effect of hypoxia on the expression of iron regulatory proteins 1 and the mechanisms involved

✍ Scribed by Qian-Qian Luo; Dan Wang; Min-Yan Yu; Li Zhu

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
540 KB
Volume
63
Category
Article
ISSN
1521-6543

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✦ Synopsis

Iron is essential for many biological processes, including oxygen delivery, and its supply is tightly regulated. Iron regulatory proteins (IRPs, IRP1 and IRP2) are master regulators of cellular iron metabolism. Hypoxia triggers a broad range of gene responses that are primarily mediated by hypoxia-inducible factor-1 (HIF-1). In this study, we have shown that hypoxia could not only upregulate the expression of hypoxia inducible factor-1 but also downregulate the expression of IRP1. However, the molecular mechanisms that govern the IRP1 response to hypoxia are not known. Herein we suggested that HIF/HRE system was an essential link between IRP1 and hypoxia. The HRE of IRP1 5 0 -regulation regions could combine with HIF-1 in vitro. Dual-luciferase reporter assay showed that IRP1 was directly downregulated by HIF/HRE system.

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