𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effects of Helicobacter pylori infection on cell cycle progression and the expression of cell cycle regulatory proteins

✍ Scribed by Antonio De Luca; Maria De Falco; Salvatore Iaquinto; Gaetano Iaquinto

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
155 KB
Volume
200
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Helicobacter pylori lives in the stomach lumen adhering and specifically interacting with gastric epithelial cells. H. pylori infection can cause a broad range of diseases. Although most infected individuals only develop a chronic inflammation of the stomach, some patients progress to chronic gastritis, duodenal ulceration, or, rarely, cancer. H. pylori is able to send and to receive signals from the gastric epithelium, allowing host and bacteria to become linked in a dynamic equilibrium. Several studies have demonstrated that H. pylori infection induces morphological changes of gastric epithelial cells other than cell proliferation, increase of mitosis and mutations. It has also been demonstrated that H. pylori may predispose to cancer by altering gastric epithelial cell turnover acting specifically on transcription factors. Although H. pylori is able to induce several host responses, it specifically perturbs the delicate balance of those factors that usually help to maintain cell homeostasis. The study of mechanisms of interaction between the bacterium and gastric cells will surely help to prevent the increase and diffusion of malignancies all over the world. © 2004 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

The Helicobacter pylori's protein VacA h
The Helicobacter pylori's protein VacA has direct effects on the regulation of cell cycle and apoptosis in gastric epithelial cells
✍ L. Manente; A. Perna; E. Buommino; L. Altucci; A. Lucariello; G. Citro; A. Baldi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 168 KB 👁 1 views

## Abstract In this study, we have evaluated the effects on cell cycle regulation of VacA alone and in combination with other two __Helicobacter pylori__ proteins, cytotoxin‐associated protein (CagA) and HspB, using the human gastric epithelial cells (AGS). Our results indicate that VacA alone was

Rnd proteins: Multifunctional regulators
Rnd proteins: Multifunctional regulators of the cytoskeleton and cell cycle progression
✍ Philippe Riou; Priam Villalonga; Anne J. Ridley 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 193 KB 👁 2 views

## Abstract Rnd3/RhoE has two distinct functions, regulating the actin cytoskeleton and cell proliferation. This might explain why its expression is often altered in cancer and by multiple stimuli during development and disease. Rnd3 together with its relatives Rnd1 and Rnd2 are atypical members of

Effects of resveratrol analogs on cell c
Effects of resveratrol analogs on cell cycle progression, cell cycle associated proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells
✍ Didier Colin; Amandine Gimazane; Gérard Lizard; Jean-Claude Izard; Eric Solary; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 601 KB

## Abstract Epidemiological studies suggested that __trans__‐resveratrol, a wine grape component, could prevent malignant tumor development. This compound also demonstrated cytostatic and cytotoxic effects on tumor cells __in vitro__. To obtain __trans__‐resveratrol derivatives with a better cellul

Effect of L-thioproline on the progressi
Effect of L-thioproline on the progression and events of the cell cycle of hela cells
✍ Rafael García Cañero; Luisa López-Alarcón; Juan José Veloso; María Del Carmen Gu 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 445 KB 👁 1 views

L-thioproline (thiazolidine-4-carboxylic acid, L-Tp) reduces DNA synthesis in cultured HeLa cells by about 50% when added to synchronized cultures at the beginning of GI phase. This inhibition is not observed when the drug is added at mid-S, in G2 or in M. L-Tp almost annuls the burst in 22Na uptake