Effects of farnesyltransferase inhibitors on cell cycle progression of human cancer cells
β Scribed by Chen Jiang; Juan Kato-Stankiewicz; Chia-Ling Gau; Fuyuhiko Tamanoi
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 129 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1438-7506
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A series of studies using farnesyltransferase (FTase) inhibitors that the inhibition of FTase function suppresses the growth of ras-transformed cells in vitro and in vivo. However, whether FTase is directly involved in the regulation of cell proliferation remains to be demonstrated. To investigate w
Background: (E)-2Π-deoxy-2Π-(fluoromethylene)-cytidine (FMdC), an irreversible inhibitor of ribonucleotide reductase, displays a strong toxicity towards many cell lines derived from human solid tumors, while its activity on leukemia lines is less well-known. The aim of this study was to assess the e
The ability of lonidamine (LND), an energolytic derivative of indazole-carboxylic acid, to modulate the cytotoxicity of Taxol (TX) was investigated in the A2780 human ovarian cancer cell line. Different cytotoxicity results were obtained as a function of treatment schedule. Specifically, TX followed