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Interleukin-1β increases binding of the iron regulatory protein and the synthesis of ferritin by increasing the labile iron pool

✍ Scribed by Domingo J. Piñero; Jing Hu; Braden M. Cook; Russell C. Scaduto Jr.; James R. Connor


Book ID
117350553
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
563 KB
Volume
1497
Category
Article
ISSN
0167-4889

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## Abstract Iron regulatory proteins (IRPs), the cytosolic proteins involved in the maintenance of cellular iron homeostasis, bind to stem loop structures found in the mRNA of key proteins involved iron uptake, storage, and metabolism and regulate the expression of these proteins in response to cha