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Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice

✍ Scribed by Boe-Hyun Kim; Yong-Chul Jun; Jae-Kwang Jin; Jae-Il Kim; Nam-Ho Kim; Elizabeth A. Leibold; James R. Connor; Eun-Kyoung Choi; Richard I. Carp; Yong-Sun Kim


Book ID
116769695
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
898 KB
Volume
422
Category
Article
ISSN
0304-3940

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## Abstract Central aspects of cellular iron metabolism are controlled by IRP1 and IRP2, which are ubiquitously expressed in mouse organs and cells. Total and constitutive deficiency of both IRPs causes embryonic lethality in the mouse. To bypass the early lethality and to study organ‐specific and/