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Effects of heavy-atom substituents on matrices used for matrix-assisted laser desorption—Ionization mass spectrometry

✍ Scribed by Lisa M. Preston-Schaffter; Gary R. Kinsel; D.H. Russell

Book ID
103995892
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
741 KB
Volume
5
Category
Article
ISSN
1044-0305

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✦ Synopsis

The data reported show that heavy-atom substitution on matrices that are used for matrix-assisted laser desorption-ionization mass spectrometry enhance M + H ion yields of both Leu-enkephalin and vitamin B12. Heavy-atom substitution alters the excited state relaxation dynamics of the matrices as indicated by measured decreases in the measured luminescence (fluorescence and/or phosphorescence) observed for heavy atoms that contain matrices relative to the nonheavy-atom-substituted matrices. The results presented are consistent with the direct involvement of an electronically excited state of the matrix in the formation of analyte M + H ions.

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