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Differentiation of enantiomers using matrix-assisted laser desorption/ionization mass spectrometry

✍ Scribed by M. P. So; T. S. M. Wan; T.-W. Dominic Chan

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 54 KB
Volume: 14
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(20000430)14:8<692::aid-rcm934>3.0.co;2-j

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✦ Synopsis

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has successfully been used to differentiate pseudo-enantiomeric (isotopically labelled) amino acids by using cyclodextrin as complexing host. By using different pseudo-enantiomeric mixtures (i.e. R Dn S; and R S Dn ), it has been demonstrated that the preference of cyclodextrin for S-enantiomers is not due to the size differences caused by the hydrogen/deuterium substitution. It is postulated that this method can be extended to differentiate enantiomers (and determine enantiomeric excess) by using a pair of enantiomeric hosts, as demonstrated previously using other ionization techniques, but with much higher sensitivity.

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