✦ LIBER ✦

Effects of crinum glaucum aqueous extract on intestinal smooth muscle activity

✍ Scribed by S. O. Okpo; O. O. Adeyemi

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 159 KB
Volume: 12
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199809)12:6<413::aid-ptr326>3.0.co;2-g

No coin nor oath required. For personal study only.

✦ Synopsis

Crinum glaucum aqueous extract (1-8 mg/mL) produced a concentration dependent, non-competitive inhibition of contractions induced by acetylcholine (1.1 Â 10 À8 -3.3 Â 10 À7 M) and calcium chloride (CaCl 2 , 0.05-2 mM) on the rat duodenum. Contractions of the guinea-pig ileum induced by acetylcholine (1.1 Â 10 À8 -3.3 Â 10 À7 M) and histamine (1.1 Â 10 À8 -3.3 Â 10 À7 M) were inhibited by the extract (1-4 mg/ mL). The extract (0.125-2.0 mg/mL) also, produced a concentration dependent relaxation of the guineapig taenia coli, precontracted with potassium chloride (40 mM).

It is concluded that the extract is a non-specific relaxant of the gastrointestinal smooth muscles used.

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