Crinum glaucum aqueous extract (1-8 mg/mL) produced a concentration dependent, non-competitive inhibition of contractions induced by acetylcholine (1.1 Â 10 À8 -3.3 Â 10 À7 M) and calcium chloride (CaCl 2 , 0.05-2 mM) on the rat duodenum. Contractions of the guinea-pig ileum induced by acetylcholine
Effect of Backebergia militaris cactus extract on intestinal smooth muscle contractility
✍ Scribed by Alma Rosa Cortés A.; Israel Gutiérrez L.; Kazuko Aoki M.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 127 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
The branches of the giant cactus Backebergia militaris contain at least one biologically active compound, corresponding to an alkaloid. This activity was not dependent on cactus age. Methanol crude extracts of B. militaris showed a clear inhibitory effect on rabbit intestinal smooth muscle contractility. The inhibitory activity was concentration-dependent, and reversible upon removal of the extract from the medium. B. militaris extract did not display any anticholinergic action on the rabbit intestine.
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