Effects of ethanol extract of Moringa stenopetala leaves on guinea-pig and mouse smooth muscle

✍ Scribed by Yalemtsehay Mekonnen

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 50 KB
• Volume: 13
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199908/09)13:5<442::aid-ptr476>3.0.co;2-7

✦ Synopsis

The fresh leaf ethanol (LE) extract of Moringa stenopetala was tested in guinea-pig ileum and mouse duodenum and in uterus strips. There were significant dose and time dependent reductions of the acetylcholine (AC) response with initial stimulatory effects in both the guinea-pig ileum and the mouse duodenum preparations. Spontaneous rhythmic contractions were greatly reduced, suggesting an antispasmodic property of the crude LE extract. The LE extract showed some oxytocic activity on uterus strips of guinea-pigs and mice. The results are indicative of the traditional use of the leaves of Moringa stenopetala for stomach pain and to expel retained placentae by women.