Analgesic Activity and Effects on Isolated Smooth Muscle of Different Fractions of Hexane Extract from Araujia sericifera Brot

✍ Scribed by R. Bello; M. D. Barrachina; J. Esplugues; M. J. López de Medrano-Villar; E. Primo-Yúfera

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 270 KB
• Volume: 10
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199606)10:4<337::aid-ptr829>3.0.co;2-z

✦ Synopsis

The present study analyses the analgesic activity and action on in vitro motility of methanol soluble and methanol insoluble fractions obtained from the hexane extract of fruits from Aruujia sericifera. The methanol fraction did not show any pharmacological activity on the different tests evaluated. However, the insoluble methanol fraction exhibited an interesting analgesic effect in models of chemical and thermal stimulus and it reduced the Em, induced by histamine in vifro on guinea-pig ileum. This extract lacked any central depressor activity since it did not modify the number of mouse movements in the activity cage.