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Effects of Commonly Used Excipients on the Expression of CYP3A4 in Colon and Liver Cells

✍ Scribed by Leslie Tompkins; Caitlin Lynch; Sam Haidar; James Polli; Hongbing Wang

Publisher
Springer US
Year
2010
Tongue
English
Weight
366 KB
Volume
27
Category
Article
ISSN
0724-8741

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Effect of cell density and epidermal gro
Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture
✍ J Greuet; L Pichard; J C Ourlin; C Bonfils; J Domergue; P Le Treut; P Maurel πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 411 KB πŸ‘ 2 views

The influence of cell density and epidermal growth factor (EGF) on the expression and inducibility of cytochrome P450 (CYP) genes of the CYP3A and CYP1A families in adult human hepatocytes in primary culture has been evaluated. Only when cultured at subconfluence and in the presence of EGF did hepat