To establish a prediction system for drug-induced gynecomastia in clinical fields, a model reaction system was developed to explain numerically this side effect. The principle is based on the assumption that 50% inhibition concentration (IC 50 ) of drugs on the in vitro metabolism of estradiol (E2)
✦ LIBER ✦
Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations
✍ Scribed by Z. E. Barter; H. F. Perrett; K. Rowland Yeo; D. Allorge; M. S. Lennard; A. Rostami-Hodjegan
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 509 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.732
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## Abstract Sumitriptan (1), a non‐selective 5‐HT~1B/1D~ agonist is an effective therapeutic agent for the acute treatment of migraine, but it is contraindicated for use in patients with known heart disease. The first Selective Serotonin One F Receptor Agonist (SSOFRA), 5‐(4′‐fluorobenz‐amido)‐3‐(_