## Abstract ## BACKGROUND. Ifosfamide is a chemotherapeutic agent that requires cytochrome P450 3A (CYP3A) for bioactivation and metabolism. To the authors' knowledge, the correlation between dose, pharmacokinetics, CYP3A, and toxicity has not been fully evaluated. A randomized Phase II trial was
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Effect of medical castration on CYP3A4 enzyme activity using the erythromycin breath test
โ Scribed by Paul R. Hutson; Kurt Oettel; Jeff Douglas; Mark Ritter; Ed Messing; Mary Jane Staab; Dona Alberti; Dorthea Horvath; George Wilding
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 211 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0344-5704
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## Abstract Covalent modification of purified __Trigonopsis variabilis__ Dโamino acid oxidase using maleimideโactivated poly(ethylene glycol) 5000 yielded a stable bioconjugate in which three surfaceโexposed cysteine side chains were selectively derivatized. Compared with the native enzyme, the PEG