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Effects of amino acids on calcium uptake by glial and neuroblastoma cells

✍ Scribed by Borg, Jacques ;Mark, Jean ;Mandel, Paul

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
607 KB
Volume
10
Category
Article
ISSN
0022-3034

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✦ Synopsis

The uptake of [45Ca] has been studied in clonal glial and neuronal cells. It was somewhat more efficient in the neuroblastoma clone MI compared to glial clones. In all cases [45Ca] uptake was shown to depend on the phosphate concentration in the incubation medium. It was decreased by the ionophore A 23187 a t 200 pM concentration in both neuronal and glial clones. The influence of amino acids some of which are putative neurotransmitters was investigated; the interactions between [45Ca] uptake and these amino acids were related to their concentration and the type of cells used (neuronal or glial). L-aspartate and taurine for example had two opposite effects on [45Ca] uptake by the glial clone NN at two different concentrations; they could therefore play a role in the control of calcium level in the synaptic cleft.

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