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Effects of polarizing currents and repetitive stimulation on the uptake of amino acids by peripheral nerve

โœ Scribed by Dr. Darrell D. Wheeler

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
478 KB
Volume
4
Category
Article
ISSN
0360-4012

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โœฆ Synopsis

The effects of polarizing currents and repetitive stimulation on the uptake of representative amino acids have been studied in peripheral nerve. Glutamic acid, lysine, pheylalanine, and GABA were chosen for study as representatives of different carrier-mediated transport mechanisms. Depolarizing currents inhibited uptakes of glutamic acid, lysine, and GABA; maximum inhibitions were 56.1 %, 20.0%. and 16.7%, respectively. Pheylalanine uptake was not inhibited by polarizing currents under any experimental conditions. Only glutamic acid uptake was inhibited by hyperpolarizing current, with a maximum inhibition of 43.9%. Stimulation had no significant effect on uptake of lysine, phenylalanine, or GABA but was found t o potentiate uptake of glutamic acid by 12%.

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