A new sustained release dosage form of valproic acid (VPA) was developed. The new sustained release dosage form was administered (twice, with and without food) to five dogs in comparison to a standard tablet (Depakine, Labaz) and an i.v. preparation of the drug. Drug level monitoring in the plasma w
Effect of sustained release on the pharmacokinetics of valproic acid in the dog
โ Scribed by Bialer, Meir; Friedman, Michael; Dubrovsky, Joseph
- Book ID
- 123320026
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 636 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0378-5173
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1. Five new sustained-release dosage forms of valproic acid (VPA) were developed. 2. The new sustained-release formulations were administered to six healthy subjects for comparison with a standard tablet and an i.v. preparation of the drug. 3. Three of the formulations exhibited a more prolonged and
To evaluate the effects of valproic acid on the disposition of phenytoin, a single dose of 600 mg valproic acid and multiple doses of valproic acid (200 mg four times a day for 5 days) were administered together with a single oral dose of 600 mg phenytoin to 12 young male volunteers. Fraction of unb