Pharmacokinetics of valproic acid in the elderly.
β Scribed by E Perucca; R Grimaldi; G Gatti; S Pirracchio; F Crema; GM Frigo
- Book ID
- 117943462
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 561 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0306-5251
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To evaluate the effects of valproic acid on the disposition of phenytoin, a single dose of 600 mg valproic acid and multiple doses of valproic acid (200 mg four times a day for 5 days) were administered together with a single oral dose of 600 mg phenytoin to 12 young male volunteers. Fraction of unb
The pharmacokinetics of free and total valproic acid (VPA) in plasma and whole blood after oral administration during steady state was investigated in seven infants (mean age 10.7 months) receiving monotherapy. The VPA concentrations in whole blood closely followed those in plasma but at a reduced l