✦ LIBER ✦

Pharmacokinetic evaluation of novel sustained-release dosage forms of valproic acid in humans

✍ Scribed by Meir Bialer; Michael Friedman; Joseph Dubrovsky; Itamar Raz; Oded Abramsky

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 444 KB
Volume: 6
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510060406

No coin nor oath required. For personal study only.

✦ Synopsis

Five new sustained-release dosage forms of valproic acid (VPA) were developed. 2. The new sustained-release formulations were administered to six healthy subjects for comparison with a standard tablet and an i.v. preparation of the drug. 3. Three of the formulations exhibited a more prolonged and uniform absorption rate and yielded more sustained serum levels after ingestion. These three formulations maintained serum therapeutic levels of VPA for 24 h after a single oral administration of 1 g, and were bioequivalent to a marketed standard tablet of VPA. 4. The absorption profile of the various oral formulations was analysed pharmacokinetically, using the Loo-Riegelman procedure.

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