✦ LIBER ✦

Pharmacokinetic analysis of sustained-release dosage forms of theophylline in humans: Comparison of single and multiple dose studies

✍ Scribed by Ziad Hussein; Meir Bialer; Michael Friedman; Itamar Raz

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 413 KB
Volume: 8
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510080503

No coin nor oath required. For personal study only.

✦ Synopsis

A pharmacokinetic analysis of two sustained-release dosage forms of theophylline (Theo-Dur@ and Theotrim@) was carried out following single and multiple dose administrations of the two formulations in five healthy subjects. Despite the prolonged absorption after administration of the two sustained-release formulations, theoretical predictions of theophylline steady-state levels following multiple dosages based upon data obtained from the single dose study, correlated with the data of the multiple dose study. This study shows that the recommended dose and dosage regimen of new sustained-release formulations of theophylline can be based upon single dose studies. In the population studied, repetitive doses of 450mg b.i.d. of Theo-Dur@ and Theotrim@ maintain steady-state concentrations of theophylline within the drug's therapeutic window.

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