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Effect of smoking on prednisone, prednisolone, and dexamethasone pharmacokinetics

โœ Scribed by James Q. Rose; Anthony M. Yurchak; A. Wayne Meikle; William J. Jusko

Book ID
112472357
Publisher
Springer
Year
1981
Tongue
English
Weight
702 KB
Volume
9
Category
Article
ISSN
1573-8744

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The nonlinear pharmacokinetics of predni
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โœ Jame S. J. Ferry; John G. Wagner ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 451 KB ๐Ÿ‘ 2 views

The protein binding characteristics of prednisone and prednisolone were determined in human and rabbit plasma and in a 4.7 per cent human serum albumin (HSA) solution. The influence of plednisolone on prednisone binding in human plasma was also examined. Prednisolone exhibited nonlinear binding and

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Three simple linear and three simple non-linear pharmacokinetic models are presented which incorporate the reversible metabolism that occurs between prednisone and prednisolone. Under steady-state conditions it is possible to not only distinguish between the linear and non-linear models but also to