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Pharmacokinetic interaction of contraceptive steroids with prednisone and prednisolone

โœ Scribed by B. M. Frey; H. J. Schaad; F. J. Frey


Publisher
Springer
Year
1984
Tongue
English
Weight
764 KB
Volume
26
Category
Article
ISSN
0031-6970

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Three simple linear and three simple non-linear pharmacokinetic models are presented which incorporate the reversible metabolism that occurs between prednisone and prednisolone. Under steady-state conditions it is possible to not only distinguish between the linear and non-linear models but also to

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The protein binding characteristics of prednisone and prednisolone were determined in human and rabbit plasma and in a 4.7 per cent human serum albumin (HSA) solution. The influence of plednisolone on prednisone binding in human plasma was also examined. Prednisolone exhibited nonlinear binding and